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49745-95-1 - Dobutamine hydrochloride - J61333 - Alfa Aesar

J61333 Dobutamine hydrochloride

Codice CAS
49745-95-1
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 78,00
1g 260,59
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Dobutamine hydrochloride

MDL
MFCD00153795
EINECS
256-464-1

Proprietà chimiche

Formula
C18H23NO3•HCl
Peso formula
337.85
Modulo
Off-white to white powder
Punto di fusione
184-186°
Solubilità
Soluble in water or ethanol with warming. Also soluble in methanol

Applicazioni

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.

Note

Solutions oxidize readily at pH greater than 11. Protect solutions from light

Letteratura

R.R.Tuttle; J.Mills. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circulation Research. 1975, 36,(1), 185-196.

 

Y.Huang; K.H.Kwok; N.W.Chan; C.W.Lau; Z.Y.Chen. Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery. Clinical and Experimental Pharmacology and Physiology. 1998, 25,(6), 405-411.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H361-H302-H312-H332

Suspected of damaging fertility or the unborn child. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Dichiarazioni precauzionali: P201-P261-P280-P281-P304+P340-P301+P312-P312-P363-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3395
Codice tariffe armonizzato
2922.29
TSCA
No

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