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104594-70-9 - Phenylethyl 3,4-dihydroxycinnamate, 99+% - 3,4-Dihydroxycinnamic acid phenylethyl ester - Phenylethyl caffeate - J61386 - Alfa Aesar

J61386 Phenylethyl 3,4-dihydroxycinnamate, 99+%

Codice CAS
104594-70-9
Sinonimi
3,4-Dihydroxycinnamic acid phenylethyl ester
Phenylethyl caffeate

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 125,00
1g 372,00
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Phenylethyl 3,4-dihydroxycinnamate, 99+%

MDL
MFCD00866470

Proprietà chimiche

Formula
C17H16O4
Peso formula
284.31
Modulo
Crystalline powder
Punto di fusione
127-129°
Sensibilità
Light Sensitive
Solubilità
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Applicazioni

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Note

Light sensitive. Incompatible with oxidizing agents and heat.

Letteratura

M.R.Fesen; Y.Pommier; F.Leteurtre; S.Hiroguchi; J.Yung; K.W.Kohn; Mark R.Fesen; Yves Pommier; Francois Leteurtre; Satoshi Hiroguchi; Jessie Yung; Kurt W.Kohn. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochemical Pharmacology. 1994, 48,(3), 595-608.

 

Z.S.Zheng; G.Z.Xue; D.Grunberger; J.H.Prystowsky. Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncology Research. 1995, 7,(9), 445-452.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2918.29
TSCA
No
RTECS
UD3334375

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