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4449-51-8 - Cyclopamine, 99% - 11-Deoxyjervine - J61528 - Alfa Aesar

J61528 Cyclopamine, 99%

Codice CAS
4449-51-8
Sinonimi
11-Deoxyjervine

Dimensioni Prezzo ($) Quantità Disponibilità
25mg 255,00
50mg 452,00
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Cyclopamine, 99%

MDL
MFCD01735266

Proprietà chimiche

Formula
C27H41NO2
Peso formula
411.62
Modulo
Powder
Punto di fusione
234-237°
Solubilità
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.

Applicazioni

Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Letteratura

Chen et al. Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 2002, 16, (21), 2743-8.

D'Amour et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat.Biotechnol. 2006, 24, (11), 1392-401.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H341-H361

Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2932.99
TSCA
No
RTECS
GY0750000

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