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32004-67-4 - Sulindac sulfide - J62104 - Alfa Aesar

J62104 Sulindac sulfide

Codice CAS
32004-67-4
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 245,00
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Sulindac sulfide

MDL
MFCD00869764
EINECS
250-892-2

Proprietà chimiche

Formula
C20H17FO2S
Peso formula
340.41
Modulo
Powder
Punto di fusione
189-191°
Solubilità
Soluble in DMSO

Applicazioni

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Letteratura

S Flis et. al. Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. Anticancer Research. 2006, 26, ( 4B), 3033-3041.

M T Taylor et. al. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Research. 2000, 60, ( 23), 6607-6610.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H334-H317-H361-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Dichiarazioni precauzionali: P285-P201-P261-P280-P281-P342+P311-P301+P312-P363-P405-P501a

In case of inadequate ventilation wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2930.90
TSCA
No
RTECS
NK8236000

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