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A tripeptide used for the reductive cleavage of disulfide bonds L-Glutathione is used in the treatment of lung diseases for patients who are HIV positive. It protects the cancerous cells by conferring resistance to chemotherapeutic drugs. It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. As an antioxidant, it prevents damage to important cellular components that arise due to reactive oxygen species like free radicals and peroxide. It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca2+ ions. It is also used in white wine production.
Deheshi, S.; Dabiri, B.; Fan, S.; Tsang, M.; Rintoul, G. L. Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling. J. Neurochem. 2015, 133 (5), 684-699.
Li, X.; Zheng, L.; Wang, Y.; Zhang, N.; Lou, Y.; Xiao, T.; Liu, J. A novel electrocatalyst with high sensitivity in detecting glutathione reduced by 2-hydroxypropyl- β-cyclodextrin enveloped 10-methylphenothiazine. RSC Adv. 2015, 5 (88), 71749-71755.