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125-84-8 - DL-Aminoglutethimide, 99% - (±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione - J62182 - Alfa Aesar

J62182 DL-Aminoglutethimide, 99%

Codice CAS
125-84-8
Sinonimi
(±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

Dimensioni Prezzo ($) Quantità Disponibilità
1g 29,70
5g 79,30
25g 297,00
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DL-Aminoglutethimide, 99%

MDL
MFCD00010122
EINECS
204-756-4

Proprietà chimiche

Formula
C13H16N2O2
Peso formula
232.28
Modulo
Powder
Punto di fusione
152-154°
Solubilità
Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.

Applicazioni

Aminoglutethimide is used to decrease the production of sex hormones and suppress the growth of tumors that need sex hormones to grow. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also a drug of abuse by body builders.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Letteratura

Imming P.; Sinning C.; Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov.2006, 5, (10), 821-34.

Siraki AG.; Bonini MG.; Jiang J.; Ehrenshaft M.; Mason RP. Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol.2007, 20, (7), 1038-45.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,440
Codice tariffe armonizzato
2925.19
TSCA
No
RTECS
MA4026950

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