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Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats. This medication is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease). It is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease
Gary G. Liversidge.; Kenneth C. Cundy. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs.Int. J. Pharm. 1995, 125 (1),91-97 .
Dichiarazioni di rischio (UE): H312-H332-H361
Harmful in contact with skin. Harmful if inhaled. Suspected of damaging fertility or the unborn child.
Dichiarazioni precauzionali: P260-P201-P280h-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.