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11089-65-9 - Tunicamycin, 95% - J62217 - Alfa Aesar

J62217 Tunicamycin, 95%

Codice CAS
11089-65-9
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
10mg 171,00
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Tunicamycin, 95%

MDL
MFCD00065709

Proprietà chimiche

Formula
C39H64N4O16
Peso formula
844.95
Modulo
Powder
Sensibilità
Moisture & Light Sensitive
Solubilità
Soluble in methanol, ethanol, DMSO, or DMF

Applicazioni

Tunicamycin has been widely used in the study of glycoprotein synthesis in various biological systems. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C Light sensitive. Moisture sensitive.

Letteratura

Ding et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 2007, 282, (7), 4702-10.

Duriez et al. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 2008, 283, (47), 32352-60.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H300-H330-H373

Fatal if swallowed. Fatal if inhaled. May cause damage to organs through prolonged or repeated exposure.

Dichiarazioni precauzionali: P260-P284-P301+P310-P304+P340-P320-P330-P310-P405-P403+P233-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9819
Beilstein
6888090
Classe di rischio
6.1
Gruppo di imballaggio
II
Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
YO7980200

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