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1393-48-2 - Thiostrepton, Streptomyces laurentii, 90+% - Bryamycin - Thiactin - J62332 - Alfa Aesar

J62332 Thiostrepton, Streptomyces laurentii, 90+%

Codice CAS
1393-48-2
Sinonimi
Bryamycin
Thiactin

Dimensioni Prezzo ($) Quantità Disponibilità
1g 168,00
5g 691,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Thiostrepton, Streptomyces laurentii, 90+%

MDL
MFCD00135828
EINECS
215-734-9

Proprietà chimiche

Formula
C72H85O18N19S5
Peso formula
1664.89
Modulo
Powder
Solubilità
Soluble in DMSO or chloroform

Applicazioni

Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1. Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures.

Note

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Letteratura

Ursula Mocek.; Zhaopie Zeng.; David O'Hagan.; Pei Zho.; Lai Duen G. Fan.; John M. Beale.; Heinz G. Floss. Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii.J. Am. Chem. Soc. 1993, 115 (18),7992-8001 .

Takahiro Suzuki.; Tsuneo Yamane.; Shoichi Shimizu. Mass production of thiostrepton by fed-batch culture of Streptomyces laurentii with pH-stat modal feeding of multi-substrate. . 1987, 25 (6),526-531 .

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9364
Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
XN6300100

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