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59721-29-8 - Camostat methanesulfate, 98% - Camostat mesylate - J62362 - Alfa Aesar

J62362 Camostat methanesulfate, 98%

Codice CAS
59721-29-8
Sinonimi
Camostat mesylate

Dimensioni Prezzo ($) Quantità Disponibilità
25mg 113,00
100mg 341,00
500mg 477,00
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Camostat methanesulfate, 98%

MDL
MFCD00941410

Proprietà chimiche

Formula
C20H22N4O5.CH3SO3H
Peso formula
494.52
Modulo
Powder
Punto di fusione
164-168°
Solubilità
Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

Applicazioni

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Letteratura

Horiuchi et al. Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 1990, 252(1), 320-6.

Ishikura et al. The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 2007, 80(21), 1999-2004.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H400-H315-H319-H335-H303

Very toxic to aquatic life. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Dichiarazioni precauzionali: P261-P273-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,1728
Classe di rischio
9
Gruppo di imballaggio
III
Codice tariffe armonizzato
2925.29
TSCA
No
RTECS
CY1571620

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