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127191-97-3 - KN-62 - J62444 - Alfa Aesar

J62444 KN-62

Codice CAS
127191-97-3
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1mg 90,70
10mg 564,00
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KN-62

MDL
MFCD00083180

Proprietà chimiche

Formula
C38H35N5O6S2
Peso formula
721.84
Modulo
Powder
Punto di fusione
65-67°
Solubilità
Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93 mg/ml), methanol (10 mg/ml), DMSO (12 mg/ml), chloroform (20 mg/ml), ethanol (~1 mg/ml), 1:2 DMF:PBS (pH 7.2) (~0.3 mg/ml), and DMF & DMSO (~30 mg/ml).

Applicazioni

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Letteratura

Okazaki K et al. KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes. J Pharmacol Exp Ther. 1994, 270, (3), 1319-24.

Tokumitsu et al. KN-62, 1-[N-O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J.Biol.Chem.. 1990, 265, (8), 4315-20.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.59
TSCA
No

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