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57444-62-9 - Resiniferatoxin, 99+% - J62458 - Alfa Aesar

J62458 Resiniferatoxin, 99+%

Codice CAS
57444-62-9
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1mg 102,18
5mg 410,97
10mg 728,21
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Resiniferatoxin, 99+%

MDL
MFCD00135927

Proprietà chimiche

Formula
C37H40O9
Peso formula
628.71
Modulo
Solid
Solubilità
Soluble in DMSO to 100mM and to 50mM in ethanol

Applicazioni

Resiniferatoxin, a potent capsaicin-like stimulator of peripheral nociceptors in the neonatal rat tail in vitro. Resiniferatoxin is used as an anti-inflammatory, anti-viral and anti-psoriatic uses. Diterpene ester related to phorbol but apparently not tumorigenic activates protein kinase C

Note

Resiniferatoxin (RTX) is susceptible to slow degradation if exposed to air. Even at -20°C, Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep in a dry place. Keep away from strong oxidizing agents. RTX must be stored in an inert atmosphere for long-term stability.

Letteratura

Szolcsanyi et al. Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J.Pharmacol.Exp.Ther. 1990, 255, (2), 923-8.

Winter et al. Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res. 1990, 520, (1-2), 131-40.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
5371150
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
3002.90
TSCA
No
RTECS
CY1633700

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