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31884-77-2 - Meclizine dihydrochloride monohydrate - J62464 - Alfa Aesar

J62464 Meclizine dihydrochloride monohydrate

Codice CAS
31884-77-2
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 33,68
5g 157,59
10g 283,25
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Meclizine dihydrochloride monohydrate

MDL
MFCD00058199

Proprietà chimiche

Formula
C25H27ClN2•2HCl•H2O
Peso formula
481.89 (463.88anhy)
Modulo
Powder
Punto di fusione
210-213°
Solubilità
Insoluble in water.

Applicazioni

Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness.

Note

Incompatible with heat and oxidizing agents.

Letteratura

Foo, W. Y. B.; Tay, H. Y.; Chan, E. C. Y.; Lau, A. J. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochem. Pharmacol. 2015, 97 (3), 320-330.

Lau, A. J.; Yang, G.; Rajaraman, G.; Baucom, C. C.; Chang, T. K. H. Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor. J. Pharmacol. Exp. Ther. 2011, 336 (3), 816-826.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H361-H302

Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Dichiarazioni precauzionali: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5777
Codice tariffe armonizzato
2933.59
TSCA
Yes

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