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70458-96-7 - Norfloxacin - Baccidal - Sebercim - J62652 - Alfa Aesar

J62652 Norfloxacin

Codice CAS
70458-96-7
Sinonimi
Baccidal
Sebercim

Dimensioni Prezzo ($) Quantità Disponibilità
1g 16,30
5g 45,80
25g 138,00
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Norfloxacin

MDL
MFCD00079532
EINECS
274-614-4

Proprietà chimiche

Formula
C16H18FN3O3
Peso formula
319.33
Modulo
Powder
Punto di fusione
220-221°
Solubilità
Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water

Applicazioni

It finds it application as a fluorinated quinolone antibacterial. It is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Note

Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.

Letteratura

Gouvea LR, et al. A typical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action.Eur J Med Chem.,2012,5567-73.

Gómez-Hurtado I, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis.Hepatology.,2011,53(3), 935-44.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6700
Codice tariffe armonizzato
2933.59
TSCA
No
RTECS
VB5005000

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