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33069-62-4 - Paclitaxel, 99.5+% - J62734 - Alfa Aesar

J62734 Paclitaxel, 99.5+%

Codice CAS
33069-62-4
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 97,34
500mg 289,43
1g 543,84
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Paclitaxel, 99.5+%

MDL
MFCD00869953

Proprietà chimiche

Formula
C47H51NO14
Peso formula
853.91
Modulo
Crystalline solid
Punto di fusione
213° dec.
Solubilità
Soluble in DMSO (200mg/ml) or ethanol (40mg/ml). Soluble in dimethylsulfoxide, methanol, ethanol, acetonitrile, cremophor and dimehtylsulfamide. Sparingly soluble in aqueous buffer.

Applicazioni

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

Note

Isolated from Taxus brevifoliaIncompatible with oxidizing agents.

Letteratura

England, C. G.; Miller, M. C.; Kuttan, A.; Trent, J. O.; Frieboes, H. B. Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles. Eur. J. Pharm. Biopharm. 2015, 92, 120-129.

Liu, Y.; Ran, R.; Chen, J.; Kuang, Q.; Tang, J.; Mei, L.; Zhang, Q.; Gao, H.; Zhang, Z.; He, Q. (2014). Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 2014, 35 (17), 4835-4847.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H334-H317-H341-H361-H318-H315-H302-H312-H332-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child. Causes serious eye damage. Causes skin irritation. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. May cause respiratory irritation.

Dichiarazioni precauzionali: P285-P201-P261-P280-P281-P305+P351+P338-P304+P340-P310-P405-P501a

In case of inadequate ventilation wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6982
Beilstein
1420457
Codice tariffe armonizzato
2932.99
TSCA
No
RTECS
DA8340700

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