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139481-59-7 - Candesartan, 98% - J62818 - Alfa Aesar

J62818 Candesartan, 98%

Codice CAS
139481-59-7
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 116,39
1g 200,00
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Candesartan, 98%

MDL
MFCD00081076

Proprietà chimiche

Formula
C24H20N6O3
Peso formula
440.45
Modulo
Powder
Punto di fusione
183-185°
Solubilità
Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Applicazioni

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Note

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Kaur N, et al. Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists.Bioorg Med Chem.,2008,16(24), 10210-5.

Nishikawa K, et al. Candesartan cilexetil: a review of its preclinical pharmacology.J Hum Hypertens.,1997,29-17.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H312-H332-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P363-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,1739
Codice tariffe armonizzato
2939.99
TSCA
No
RTECS
DD6671000

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