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51481-61-9 - Cimetidine, 98+% - 1-Cyano-3-methyl-2-[2-(5-methyl-4-imidazolylmethylthio)ethyl]guanidine - SKF-92334 - J62825 - Alfa Aesar

J62825 Cimetidine, 98+%

Codice CAS
51481-61-9
Sinonimi
1-Cyano-3-methyl-2-[2-(5-methyl-4-imidazolylmethylthio)ethyl]guanidine
SKF-92334

Dimensioni Prezzo ($) Quantità Disponibilità
5g 70,40
10g 95,90
25g 204,00
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Cimetidine, 98+%

MDL
MFCD00133296
EINECS
257-232-2

Proprietà chimiche

Formula
C10H16N6S
Peso formula
252.34
Modulo
Powder
Punto di fusione
139-144°
Solubilità
Soluble to 50 mM in water and to 100 mM in DMSO, solubility in HCl (almost transparency).

Applicazioni

Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. It displays antitumor and immunomodulatory activity. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent and is an activator of Nischarin. Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

Note

Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Yasui-Furukori N, et al. Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.Clinical pharmacology and therapeutics.,2005,77(1), 17-23.

Yoshizawa F, et al. Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.Journal of clinical pharmacology.,1981,21(2), 87-91.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H360-H303

May damage fertility or the unborn child. May be harmful if swallowed.

Dichiarazioni precauzionali: P201-P281-P202-P312-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,2279
Codice tariffe armonizzato
2933.29
TSCA
No
RTECS
MF0035500

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