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Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality.
Kohno, T.; Ninomiya, T.; Kikuchi, S.; Konno, T.; Kojima, T. Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts. Mol. Pharmacol. 2015, 87 (5), 815-824.
Lee, H. G.; Kim, D. S.; Moon, S. A.; Kang, J. W.; Seo, J. T. Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes. Int. J. Oral Biol. 2015, 40 (1), 27-33.
Dichiarazioni di rischio (UE): H350
May cause cancer.
Dichiarazioni precauzionali: P201-P280-P202-P308+P313-P405-P501a
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