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It shows anti-inflammatory and chemo preventive effects in vivo. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells. It is also used in fortified foods and supplements. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy. Children and adults both require folic acid to produce healthy red blood cells and prevent anemia.
DebRoy S et al. A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization. PLoS One .2013, 8, (7), e70062-66.
Obeid R The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients .2013, 5, (9), 3481-95.