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59-05-2 - Methotrexate - J63075 - Alfa Aesar

J63075 Methotrexate

Codice CAS
59-05-2
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 113,30
1g 576,80
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Methotrexate

MDL
MFCD00150847
EINECS
200-413-8

Proprietà chimiche

Formula
C20H22N8O5
Peso formula
454.44
Modulo
Powder
Sensibilità
Light Sensitive & Hygroscopic
Solubilità
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Applicazioni

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Letteratura

Allegra et al. Evidence for direct inhibition of de novo protein synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J.Biol.Chem. 1987, 262, (28), 13520-6.

Cronstein, B. N. Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis. Pharmacological Reviews . 2005, 57, (2), 163-172.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H315-H319-H360

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May damage fertility or the unborn child.

Dichiarazioni precauzionali: P201-P280-P281-P301+P310-P305+P351+P338-P362-P308+P313-P321-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5985
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2933.59
TSCA
Yes
RTECS
MA1225000

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