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10236-47-2 - Naringin - 4',5,7-Trihydroxyflavanone 7-rhamnoglucoside - J63166 - Alfa Aesar

J63166 Naringin

Codice CAS
10236-47-2
Sinonimi
4',5,7-Trihydroxyflavanone 7-rhamnoglucoside

Dimensioni Prezzo ($) Quantità Disponibilità
25g 31,50
100g 112,00
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Naringin

MDL
MFCD00148888
EINECS
233-566-4

Proprietà chimiche

Formula
C27H32O14
Peso formula
580.53
Modulo
Powder
Solubilità
Soluble in water, alcohol, acetone and warm acetic acid.

Applicazioni

A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer's disease.

Note

Incompatible with strong oxidizing agents.

Letteratura

Nguyen, M. A.; Staubach, P.; Tamai, I.; Langguth, P. High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans. Eur. J. Pharm. Sci. 2015, 68, 36-42.

Pai, D. A.; Vangala, V. R.; Ng, J. W.; Ng, W. K.; Tan, R. B. H. Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization. J. Food Eng. 2015, 161, 68-74.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P312a-P321-P332+P313-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6425
Beilstein
102012
Codice tariffe armonizzato
2938.90
TSCA
Yes
RTECS
QN6340000

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