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Inhibitor of protein kinase C and induces apoptosis in cancer cells Tamoxifen is used in the treatment of both early and advanced estrogen receptor positive breast cancer in pre- and post-menopausal women. It is also used in the treatment of infertility in women with anovulatory disorders as well as to prevent estrogen-related gynecomastia. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.
Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.
Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.
Dichiarazioni di rischio (UE): H350-H360-H362
May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.
Dichiarazioni precauzionali: P263-P260u-P201-P280-P405-P501a
Avoid contact during pregnancy/while nursing. Do not breathe dusts or mists. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.