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J63509 Tamoxifen, 98%

Codice CAS
10540-29-1
Sinonimi
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
J63509-ME 500mg 88,30
J63509-03 1g 149,00
J63509-06 5g 642,00
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Tamoxifen, 98%

MDL
MFCD00010454
EINECS
234-118-0

Proprietà chimiche

Formula
C26H29NO
Peso formula
371.52
Modulo
Powder
Storage & Sensitivity
Store at -20°C.
Solubilità
Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.

Applicazioni

Inhibitor of protein kinase C and induces apoptosis in cancer cells Tamoxifen is used in the treatment of both early and advanced estrogen receptor positive breast cancer in pre- and post-menopausal women. It is also used in the treatment of infertility in women with anovulatory disorders as well as to prevent estrogen-related gynecomastia. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

Note

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Letteratura

Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.

Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H350-H360-H362

May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.

Dichiarazioni precauzionali: P263-P260u-P201-P280-P405-P501a

Avoid contact during pregnancy/while nursing. Do not breathe dusts or mists. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9048
Codice tariffe armonizzato
2922.29
TSCA
No
RTECS
KR5919600

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