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51803-78-2 - Nimesulide - N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide - J63699 - Alfa Aesar

J63699 Nimesulide

Codice CAS
51803-78-2
Sinonimi
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

Dimensioni Prezzo ($) Quantità Disponibilità
5g 48,70
25g 204,00
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Nimesulide

MDL
MFCD00079470
EINECS
257-431-4

Proprietà chimiche

Formula
C13H12N2O5S
Peso formula
308.31
Modulo
Needle-like crystals
Punto di fusione
145-147°
Solubilità
Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.

Applicazioni

Nimesulide are used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, . Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. It was effective in reducing pain associated with osteoarthritis, cancer, thrombophlebitis, oral surgery in adults, otorhinolaryngological diseases and traumatic injury. Nimesulide is demonstrated to suppress azoxymethane-induced carcinogenesis.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

Rick Davis,; Rex N. Brogden.Nimesulide, An Update of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy. Drugs. Drugs, 199448 (3), 431-454.

Alberto Bernaregg. Clinical Pharmacokinetics of Nimesulide. Clinical Pharmacokinetics. 1995, 35 (4), 247-274.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301

Toxic if swallowed.

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6548
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2935.90
TSCA
No
RTECS
PB0970000

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