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Potent inhibitor of protein synthesis in bacteria.Apramycin sulfate is used as a potent inhibitor of protein synthesis in bacteria. It acts as an antibacterial agent. It is a useful biochemical for antibiotic and antibacterial research to study antibiotic resistance through protein synthesis inhibition by blocking translocation. It is also essential for clinic in vitro tests known as antimicrobial susceptibility tests to determine their efficacy against certain bacterial species.
Zhang, X. Y.; Ding, L. J.; Fan, M. Z. Resistance patterns and detection of aac(3)-IV gene in apramycin-resistant Escherichia coli isolated from farm animals and farm workers in northeastern of China. Res. Vet. Sci. 2009, 87 (3), 449-454.
Haritova, A. M.; Djeneva, H. A.; Lashev, L. D.; Sotirova, P. G.; Gurov, B. I.; Dyankov, V. N. Pharmacokinetics of gentamicin and apramycin in turkeys roosters and hens in the context of pharmacokinetic-pharmacodynamic relationships. J. Vet. Pharmacol. Ther. 2004, 27 (5), 381-384.
Dichiarazioni di rischio (UE): H315-H319-H360
Causes skin irritation. Causes serious eye irritation. May damage fertility or the unborn child.
Dichiarazioni precauzionali: P201-P280-P305+P351+P338-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.