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Imiquimod is a caspase 3 activator which acts as an immunomodulator and displays antiviral and anti-tumor activity. It is a patient-applied cream used for the treatment of genital warts and basal cell carcinoma. It is also used to cure actinic keratosis on the face and scalp. It belongs to a group of drugs called immune response modifiers, which work by activating the immune system to fight abnormal skin growth.
Arits, A., Nelemans, P.; Smeets, N. K. Response to Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial: a critical appraisal. Br. J. Dermatol. 2015, 172 (1), 11-12.
Kono, T.; Biswas, G.; Fall, J.; Mekata, T.; Hikima, J. I.; Itami, T.; Sakai, M. Adjuvant effects of poly I: C and imiquimod on the immunization of kuruma shrimp (Marsupenaeus japonicus) with a recombinant protein, VP28 against white spot syndrome virus. Aquaculture 2015, 446, 236-241.
Dichiarazioni di rischio (UE): H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.