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Fluocinolone acetonide is primarily used in dermatology to reduce skin inflammation and relieve itching. It acts as an inhibitor of tumor cells and it can regulate lipid metabolism by modulating gene expression. It can also inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, it can inhibit TNF-α angiogenesis.
Glenn J.Jaffe, MD; Joshua Ben-nun, MD; Hong Guo, PhD; James P.Dunn, MD; Paul Ashton, PhD. Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. Ophthalmology. 2000, 107,(11), 2024-2033.
B.J.Poulsen; E.Young; V.Coquilla; M.Katz. Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester. Journal of Pharmaceutical Sciences. 1968, 57,(6), 928-933.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.