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25316-40-9 - Doxorubicin hydrochloride - 14-Hydroxydaunomycin - J64000 - Alfa Aesar

J64000 Doxorubicin hydrochloride

Codice CAS
25316-40-9
Sinonimi
14-Hydroxydaunomycin

Dimensioni Prezzo ($) Quantità Disponibilità
10mg 167,00
50mg 352,00
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Doxorubicin hydrochloride

MDL
MFCD00077757
EINECS
246-818-3

Proprietà chimiche

Formula
C27H29NO11•HCl
Peso formula
579.99
Modulo
Solid
Punto di fusione
216° dec.
Solubilità
Soluble in water.

Applicazioni

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs.

Note

Moisture and light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Letteratura

Benival, D. M.; Devarajan, P. V. In Situ Lipidization as a New Approach for the Design of a Self Microemulsifying Drug Delivery System (SMEDDS) of Doxorubicin Hydrochloride for Oral Administration. J. Biomed. Nanotechnol. 2015, 11 (5), 913-922.

Esmaeili, A.; Hadad, N. A. Preparation of ZnFe2O4-chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics. Ceram. Int. 2015, 41 (6), 7529-7535.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H350

Harmful if swallowed. May cause cancer.

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3439
Beilstein
4229251
Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
QI9295900

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