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25316-40-9 - Doxorubicin hydrochloride - 14-Hydroxydaunomycin - J64000 - Alfa Aesar

J64000 Doxorubicin hydrochloride

Codice CAS
25316-40-9
Sinonimi
14-Hydroxydaunomycin

Dimensioni Prezzo ($) Quantità Disponibilità
10mg 165,83
50mg 348,14
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Doxorubicin hydrochloride

MDL
MFCD00077757
EINECS
246-818-3

Proprietà chimiche

Formula
C27H29NO11•HCl
Peso formula
579.99
Modulo
Solid
Punto di fusione
216° dec.
Solubilità
Soluble in water.

Applicazioni

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs.

Note

Moisture and light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Letteratura

Benival, D. M.; Devarajan, P. V. In Situ Lipidization as a New Approach for the Design of a Self Microemulsifying Drug Delivery System (SMEDDS) of Doxorubicin Hydrochloride for Oral Administration. J. Biomed. Nanotechnol. 2015, 11 (5), 913-922.

Esmaeili, A.; Hadad, N. A. Preparation of ZnFe2O4-chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics. Ceram. Int. 2015, 41 (6), 7529-7535.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H350-H302

May cause cancer. Harmful if swallowed.

Dichiarazioni precauzionali: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3439
Beilstein
4229251
Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
QI9295900

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