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94497-51-5 - Tamibarotene - AM 80 - J64028 - Alfa Aesar

J64028 Tamibarotene

Codice CAS
94497-51-5
Sinonimi
AM 80

Dimensioni Prezzo ($) Quantità Disponibilità
10mg 122,00
50mg 612,00
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Tamibarotene

MDL
MFCD00866188

Proprietà chimiche

Formula
C22H25NO3
Peso formula
351.44
Modulo
Solid
Solubilità
Soluble to 50 mM in DMSO

Applicazioni

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.

Note

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Letteratura

B.A.Bernard; J.M.Bernardon; C.Delescluse; B.Martin; M.C.Lenoir; J.Maignan; B.Charpentier; W.R.Pilgrim; U.Reichert; B.Shroot. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992, 186,(2), 977-983.

 

Shiro Jimi; Kota Mashima; Taichi Matsumoto; Shuji Hara; Junji Suzumiya; Kazuo Tamura. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. International Journal of Oncology. 2007, 31,(2), 397-404.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9047
Codice tariffe armonizzato
2924.29
TSCA
No
RTECS
DH6940000

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