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5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
Siva P. Kumpatla.; Timothy C. Hall. Longevity of 5-azacytidine-mediated gene expression and re-establishment of silencing in transgenic rice. Plant Molecular Biology. 1998, 38, (6), 1113-1122.
Sunil Rangappa.; Chen Fen.; Eng Hin Lee.; Ariff Bongso.; Eugene Sim Kwang Wei. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. The Annals of Thoracic Surgery. 2003, 75, (3), 775-779.
Dichiarazioni di rischio (UE): H302-H340-H350
Harmful if swallowed. May cause genetic defects. May cause cancer.
Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.