Bax Channel Blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 M). It is suggested to inhibit Bax (Bcl-2-associated X protein) channel formation and activity.
Agnes Bombrun; Patrick Gerber; Giulio Casi; Olivier Terradillos; Bruno Antonsson; Serge Halazy. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax Channel Modulation. J. Med. Chem. 2003, 46,(21), 4365-4368.
Elisabete Ferreiro; Catarina R.Oliveira; Claudia M.F.Pereira. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiology of Disease. 2008, 30,(3), 331-342.
Dichiarazioni di rischio (UE): H341
Suspected of causing genetic defects.
Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a