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335165-69-0 - Bax Channel Blocker - 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol bis(trifluoracetate) salt - J64257 - Alfa Aesar

J64257 Bax Channel Blocker

Codice CAS
335165-69-0
Sinonimi
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol bis(trifluoracetate) salt

Dimensioni Prezzo ($) Quantità Disponibilità
10mg 154,00
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Bax Channel Blocker

MDL
MFCD09037523

Proprietà chimiche

Formula
C19H21Br2N3O.2CF3CO2H
Peso formula
695.24
Modulo
Powder
Sensibilità
Light Sensitive & Hygroscopic
Solubilità
Soluble in water at 5mM or in DMSO at 100mM

Applicazioni

Bax Channel Blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 M). It is suggested to inhibit Bax (Bcl-2-associated X protein) channel formation and activity.

Note

Light sensitive and hygroscopic. Incompatible with oxidizing agents and heat.

Letteratura

Agnes Bombrun; Patrick Gerber; Giulio Casi; Olivier Terradillos; Bruno Antonsson; Serge Halazy. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax Channel Modulation. J. Med. Chem. 2003, 46,(21), 4365-4368.

 

Elisabete Ferreiro; Catarina R.Oliveira; Claudia M.F.Pereira. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiology of Disease. 2008, 30,(3), 331-342.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H341

Suspected of causing genetic defects.

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
3822.00
TSCA
No

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