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3483-12-3 - 1,4-Dithio-DL-threitol, Electrophoresis Grade, 99% - Cleland's Reagent DTT racemic - (±)-threo-1,4-Dimercapto-2,3-butanediol - J64545 - Alfa Aesar

J64545 1,4-Dithio-DL-threitol, Electrophoresis Grade, 99%

Codice CAS
3483-12-3
Sinonimi
Cleland's Reagent DTT racemic
(±)-threo-1,4-Dimercapto-2,3-butanediol

Dimensioni Prezzo ($) Quantità Disponibilità
1g 34,30
5g 92,49
25g 375,95
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1,4-Dithio-DL-threitol, Electrophoresis Grade, 99%

MDL
MFCD00004877
EINECS
222-468-7

Proprietà chimiche

Formula
C4H10O2S2
Peso formula
154.25
Modulo
Powder
Punto di fusione
40-43°
Punto di ebollizione
125-130°/12mm
Punto di infiammabilità
>110°(230°F)
Sensibilità
Air Sensitive
Solubilità
Soluble in water, ethanol, chloroform, diethyl ether, acetone, ether and ethyl acetate.

Applicazioni

1,4-Dithio-DL-threitol is used as a protective agent for preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.

Note

Air and heat sensitive. Hygroscopic. Incompatible with strong oxidizing agents, reducing agents and alkalies.

Letteratura

Tobolkina, E.; Salazar, F. C.; Qiao, L.; Girault, H. H. Protein/peptide purification by three-well OFFGEL electrophoresis with immobilized ultra narrow pH gradient gels. 2014, 6 (12), 3995-4002.

Fujita, K.; Muraki, T.; Sakurai, T.; Oishi, A.; Taguchi, Y. Synthesis of Novel Dendritic α-Glycol Ligands Derived from DL-Dithiothreitol and Their Application to Ring-opening Polymerization of ε-Caprolactone. Chem. Lett. 2004, 34 (8), 1180-1181.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3376
Beilstein
1719757
Codice tariffe armonizzato
2930.90
TSCA
Yes
RTECS
EK1610000

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