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28822-58-4 - 3-Isobutyl-1-methylxanthine - 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione - Phosphodiesterase Inhibitor (IBMX) - J64598 - Alfa Aesar

J64598 3-Isobutyl-1-methylxanthine

Codice CAS
28822-58-4
Sinonimi
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Phosphodiesterase Inhibitor (IBMX)

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 41,20
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3-Isobutyl-1-methylxanthine

MDL
MFCD00005584
EINECS
249-259-3

Proprietà chimiche

Formula
C10H14N4O2
Peso formula
222.24
Modulo
Solid
Punto di fusione
200-201°
Solubilità
Soluble in ethanol.

Applicazioni

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.

Note

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Letteratura

Stephen C. Mann.; Paul A. Andrews.; Stephen B. Howell. Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells. International Journal of Cancer. 1991, 48, (6), 866-872.

Friedman, G.; Chajek-Shaul, T.; Stein, O.; Stein, Y. Modulation of lipoprotein lipase activity in cultured rat mesenchymal heart cells and preadipocytes by dibutyryl cyclic amp, cholera toxin and 3-isobutyl- 1-methylxanthine. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 752, (1), 106-117.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302

Harmful if swallowed.

Dichiarazioni precauzionali: P264-P270-P301+P312a-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.59
TSCA
No
RTECS
ZD8500000

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