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42155-08-8 - 2'-Deoxyuridine-5'-monophosphate disodium salt, 99% - 2'-dUMP - 2'-Deoxyuridine-5'-monophosphoric acid disodium salt - J64627 - Alfa Aesar

J64627 2'-Deoxyuridine-5'-monophosphate disodium salt, 99%

Codice CAS
42155-08-8
Sinonimi
2'-dUMP
2'-Deoxyuridine-5'-monophosphoric acid disodium salt

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 85,70
1g 172,00
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2'-Deoxyuridine-5'-monophosphate disodium salt, 99%

MDL
MFCD00065282
EINECS
255-687-1

Proprietà chimiche

Formula
C9H11N2Na2O8P
Peso formula
352.15
Modulo
Powder
Solubilità
Soluble in water.

Applicazioni

2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

Note

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Letteratura

Ruth L. Saxl.; James Reston.; Zhe Nie.; Thomas I. Kalman.; Frank Maley. Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2‘-deoxyuridine 5‘-Monophosphate. Biochemistry. 2003, 42 (15), 4544-4551.

Mikhail V. Rekharsky.; Asao Nakamura.; Guy A. Hembury.; Yoshihisa Inoue. Thermodynamic Study of the Discrimination between Uridine and Thymidine Derivatives by Hydrophobic, Stacking, and Intercalating Interactions. Bulletin of the Chemical Society of Japan. 2001, 74 (3), 449-457.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.99
TSCA
No

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