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300801-52-9 - Cdc2-Like Kinase Inhibitor, TG003 - Clk Inhibitor - TG003 - J64690 - Alfa Aesar

J64690 Cdc2-Like Kinase Inhibitor, TG003

Codice CAS
300801-52-9
Sinonimi
Clk Inhibitor
TG003

Dimensioni Prezzo ($) Quantità Disponibilità
5mg 70,74
50mg 471,60
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Cdc2-Like Kinase Inhibitor, TG003

MDL
MFCD00624584

Proprietà chimiche

Formula
C13H15NO2S
Peso formula
249.33
Modulo
Solid
Sensibilità
Light Sensitive
Solubilità
Soluble in DMSO

Applicazioni

Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.

Note

Keep container tightly closed. Store in cool, dry conditions in well sealed containers. It is sensitive to light.

Letteratura

Yasushi Ogawa.; Yosuke Nonaka.; Toshiyasu Goto.; Eriko Ohnishi.; Toshiyuki Hiramatsu.; Isao Kii.; Miyo Yoshida.; Teikichi Ikura.; Hiroshi Onogi.; Hiroshi Shibuya.; Takamitsu Hosoya.; Nobutoshi Ito.; Masatoshi Hagiwara. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature Communications. 2010, 1 86.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.20
TSCA
No

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