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2627-69-2 - 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98% - Acadesine - AICAR - J64720 - Alfa Aesar

J64720 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%

Codice CAS
2627-69-2
Sinonimi
Acadesine
AICAR

Dimensioni Prezzo ($) Quantità Disponibilità
50mg 110,00
200mg 265,00
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5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%

MDL
MFCD00869751
EINECS
220-097-5

Proprietà chimiche

Formula
C9H14N4O5
Peso formula
258.23
Modulo
Powder
Punto di fusione
214-215°
Solubilità
Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

Applicazioni

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Note

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Letteratura

Lee A. Witters. The blooming of the French lilac. J Clin Invest. 2001, 108, (8), 1105-1107.

Yu, X.; McCorkle, S.; Wang, M.; Lee, Y.; Li, J.; Saha, A.K.; Unger, R.H.; Ruderman, N.B. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004, 47, (11), 2012-2021.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,16
Codice tariffe armonizzato
2934.99
TSCA
Yes

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