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478336-92-4 - MIF Antagonist, ISO-1 - (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester - Macrophage Migration Inhibitory Factor Antagonist - J64947 - Alfa Aesar

J64947 MIF Antagonist, ISO-1

Codice CAS
478336-92-4
Sinonimi
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Macrophage Migration Inhibitory Factor Antagonist

Dimensioni Prezzo ($) Quantità Disponibilità
5mg 103,00
25mg 411,00
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MIF Antagonist, ISO-1

MDL
MFCD22376813

Proprietà chimiche

Formula
C12H13NO4
Peso formula
235.24
Modulo
Solid
Sensibilità
Light Sensitive
Solubilità
Soluble in DMSO.

Applicazioni

MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.

Note

Light Sensitive. Keep container tightly closed. Store away from oxidizing agents.

Letteratura

Stanislava Stosic-Grujicic.; Ivana Stojanovic.; Ferdinando Nicoletti. MIF in autoimmunity and novel therapeutic approaches. Autoimmunity Reviews. 2009, 8, (3), 244-249.

Benjamin W. Fischer-Valuck.; Bonnie L. Barrilleaux.; Donald G. Phinney.; Katie C. Russell.; Darwin J. Prockop.; Kim C. O Connor. Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency. Biotechnology Letters. 2010, 32, (1), 19-27.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.99
TSCA
No

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