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Transforming Growth Factor-β1 is a multifunctional protein capable of influencing cell proliferation, differentiation, and a variety of cellular functions. TGF-β stimulates the growth of cells of mesenchymal origin, but inhibits growth of hepatocytes, T and B lymphocytes and epithelial cells. TGF-β is known to interact with several agents including EGF, FGF, TGF-α, PDGF, and IL-2. TGF-β is an important mediator of the formation of the extracellular matrix, generally with activities that stimulate the formation of the extracellular matrix and inhibit the degradation of the extracellular matrix. TGF-β is a potent inhibitor of the myogenesis of both skeletal and cardiac muscle cells in vitro. Porcine TGF-β1 is identical in amino acid composition to human TGF-β1.
Oka, Y.; Orth, D.N. Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets. J Clin Invest. 1983, 72, (1), 249-259.
Steven B. Nicoll.; Shulamith Radin.; Eric M. Santos.; Rocky S. Tuan.; Paul Ducheyne. In vitro release kinetics of biologically active transforming growth factor-β1 from a novel porous glass carrier ?. Biomaterials. 1997, 18, (12), 853-859.
Dichiarazioni di rischio (UE): H225-H313-H333-H319
Highly flammable liquid and vapour. May be harmful in contact with skin. May be harmful if inhaled. Causes serious eye irritation.
Dichiarazioni precauzionali: P210-P280a-P240-P303+P361+P353-P305+P351+P338-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Dispose of contents/container in accordance with local/regional/national/international regulations.