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Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase. Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling. Cell-permeable adenylate cyclase inhibitor; in detergent-dispersed rat brain preparation, IC50 = 30 ?M. Clinically significant antiviral agent, especially against herpes simplex (HSV),1 by inhibition of DNA polymerase.
Gene D. Morse.; Mark J. Shelton.; Alice M. O Donnell. Comparative Pharmacokinetics of Antiviral Nucleoside Analogues. Clinical Pharmacokinetics. 1993, 24, (2), 101-123.
John A. SecristIII.; Anita T. Shortnacy.; John A. Montgomery. Synthesis and biological evaluations of certain 2-halo-2'-substituted derivatives of 9-.beta.-D-arabinofuranosyladenine. J. Med. Chem. 1988, 31, (2), 405-410.
Dichiarazioni di rischio (UE): H361
Suspected of damaging fertility or the unborn child.
Dichiarazioni precauzionali: P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.