3'-Azido-3'-deoxythymidine is a Anti-viral agent, and also used as a reverse transcriptase inhibitor active against HIV-1 virus that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3?-Azido-3?-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.
Hashem Heiati.; Rashad Tawashi.; Nigel C Phillips. Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3?-azido-3?-deoxythymidine palmitate in mice. International Journal of Pharmaceutics. 1998, 174, (1-2), 71-80.
Chris Meier.; Eric De Clercq.; Jan Balzarini. Nucleotide Delivery from cycloSaligenyl-3?-azido-3?-deoxythymidine Monophosphates (cycloSal-AZTMP). European Journal of Organic Chemistry. 1998, 1998, (5), 837-846.
Dichiarazioni di rischio (UE): H303-H351
May be harmful if swallowed. Suspected of causing cancer.
Dichiarazioni precauzionali: P201-P280-P312a-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.