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51050-59-0 - 3,4-Dichloroisocoumarin, 99% - 3,4-Dichloro-2-benzopyran-1-one - 3,4-DCI - J65198 - Alfa Aesar

J65198 3,4-Dichloroisocoumarin, 99%

Codice CAS
51050-59-0
Sinonimi
3,4-Dichloro-2-benzopyran-1-one
3,4-DCI

Dimensioni Prezzo ($) Quantità Disponibilità
10mg 253,91
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3,4-Dichloroisocoumarin, 99%

MDL
MFCD00036960

Proprietà chimiche

Formula
C9H4Cl2O2
Peso formula
215.03
Modulo
Powder
Solubilità
Soluble in DMF or DMSO at a concentration of 10mM

Applicazioni

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.

Note

Effective concentration 5-100 M. 3,4-DCI has a half life of 20 minutes at pH 7.5.

Letteratura

Nadia Korfali; Elizabeth A L Fairley; Selene K Swanson; Laurence Florens; Eric C Schirmer. Use of sequential chemical extractions to purify nuclear membrane proteins for proteomics identification. Methods in Molecular Biology. 2009, 528, 201-225.

J W Harper; K Hemmi; J C Powers. Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor. Biochemistry (Washington). 1985, 24, (8), 1831-1841.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
6802625
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2932.20
TSCA
No

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