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93438-65-4 - Conantokin G - Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH<sub>2</sub> - J66100 - Alfa Aesar

J66100 Conantokin G

Codice CAS
93438-65-4
Sinonimi
Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2

Dimensioni Prezzo ($) Quantità Disponibilità
5mg 258,00
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Conantokin G

MDL
MFCD00214606

Proprietà chimiche

Formula
C88H138N26O44
Peso formula
2264.18
Modulo
Solid
Solubilità
Soluble in water at 1mg/ml

Applicazioni

Non-competitive inhibitor of NMDA glutamatergic receptors acting at the polyamine site. Conantokin G (CGX-1007), a member of the conantokin family, is a selective NR2B subunit inhibitor of NMDA glutamatergic receptors with activity as a neuroprotective agent against NMDA-induced excitotoxicity.

Note

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Letteratura

Lance G. Hammerland.; Baldomero M. Olivera.; Doju Yoshikami. Conantokin-G selectively inhibits N-methyl-D-aspartate-induced currents in Xenopus oocytes injected with mouse brain mRNA. European Journal of Pharmacology: Molecular Pharmacology. 1992, 226, (3), 239-244.

Mary Prorok.; Scott E. Warder.; Tamas Blandl.; Francis J. Castellino. Calcium Binding Properties of Synthetic γ-Carboxyglutamic Acid-Containing Marine Cone Snail “Sleeper” Peptides, Conantokin-G and Conantokin-T. Biochemistry. 1996, 35, (51), 16528-16534.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2925.29
TSCA
No
RTECS
GK5900000

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