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15220-11-8 - 4-Methylumbelliferyl sulfate potassium salt, 98% - J66160 - Alfa Aesar

J66160 4-Methylumbelliferyl sulfate potassium salt, 98%

Codice CAS
15220-11-8
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
500mg 100,00
1g 180,00
5g 360,00
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4-Methylumbelliferyl sulfate potassium salt, 98%

MDL
MFCD00016970
EINECS
239-272-2

Proprietà chimiche

Formula
C10H7KO6S
Peso formula
294.32
Modulo
Powder
Solubilità
Soluble in water at 5mg/ml

Applicazioni

4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.

Note

Excitation wavelength, 334 nm; emission wavelength, 370nm (pH 10.4). Reaction product: excitiation wavelength, 360nm; emission wavelength, 449nm

Letteratura

Ch. Meyer, J.; Grundmann, H.P.; Schnyder, U.W. Determination of arylsulfatase C in hair follicles. Archives of Dermatological Research. 1979, 266, (1), 95-97.

Rosa Bartolomeo.; Elena V. Polishchuk.; Nicola Volpi.; Roman S. Polishchuk.; Alberto Auricchio. Pharmacological read-through of nonsense ARSB mutations as a potential therapeutic approach for mucopolysaccharidosis VI. Archives of Dermatological Research. 2013, 36, (2), 363-371.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3803203
Codice tariffe armonizzato
2932.20
TSCA
Yes

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