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70476-82-3 - Mitoxantrone dihydrochloride - 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride - J66341 - Alfa Aesar

J66341 Mitoxantrone dihydrochloride

Codice CAS
70476-82-3
Sinonimi
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

Dimensioni Prezzo ($) Quantità Disponibilità
50mg 118,45
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Mitoxantrone dihydrochloride

MDL
MFCD00242943
EINECS
274-619-1

Proprietà chimiche

Formula
C22H28N4O6.2HCl
Peso formula
517.40
Modulo
Crystalline solid
Solubilità
Soluble to 5 mM in water and to 75 mM in DMSO

Applicazioni

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

Note

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Letteratura

Geoffrey R. Fisher.; Laurence H. Patterson. DNA strand breakage by peroxidase-activated mitoxantrone. Journal of Pharmacy and Pharmacology. 1991, 43, (1), 65-68.

Reginald Hulhoven.; Etienne Dumont.; Carl Harvengt. Plasma kinetics of mitoxantrone in leukemic patients. Medical Oncology and Tumor Pharmacotherapy. 1984, 3, (1), 201-204.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H310-H302-H340-H360

Fatal in contact with skin. Harmful if swallowed. May cause genetic defects. May damage fertility or the unborn child.

Dichiarazioni precauzionali: P201-P262-P280-P281-P361-P302+P350-P310-P301+P312-P405-P501a

Obtain special instructions before use. Do not get in eyes, on skin, or on clothing. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6217
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2922.50
TSCA
No
RTECS
CB5748500

Raccomandato

  • A11880

    2-Hydroxy-1,4-naphthoquinone, 98+%
  • A18930

    5,8-Dihydroxy-1,4-naphthoquinone, 97%

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