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84625-61-6 - Itraconazole, 98% - Oriconazole - R51211 - J66390 - Alfa Aesar

J66390 Itraconazole, 98%

Codice CAS
84625-61-6
Sinonimi
Oriconazole
R51211

Dimensioni Prezzo ($) Quantità Disponibilità
1g 71,40
5g 143,00
25g 608,00
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Itraconazole, 98%

MDL
MFCD00870168

Proprietà chimiche

Formula
C35H38Cl2N8O4
Peso formula
705.63
Modulo
Powder
Punto di fusione
166°
Punto di infiammabilità
>110°(230°F)
Solubilità
Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol

Applicazioni

Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats..

Note

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Letteratura

Katsuhisa Uchida; Kosuke Shimogawara; Hideyo Yamaguchi. Correlation of in vitro activity and in vivo efficacy of itraconazole intravenous and oral solubilized formulations by testing Candida strains with various itraconazole susceptibilities in a murine invasive infection. Journal of Antimicrobial Chemotherapy.2011, 66, (3), 626-634.

Tomoya Sano; Kiyokazu Ozaki; Yasushi Kodama; Tetsuro Matsuura; Isao Narama. Effects of the antifungal agent itraconazole on proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats. Toxicologic Pathology.2009, 37, (6), 790-798.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5245
Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
XZ5481000

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