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Tazobactam is a drug is used in conjunction with beta-lactamase susceptible penicillins to treat infections caused by beta-lactamase producing organisms. It acts as a beta lactamase inhibitor. It is used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action. It is used as antibiotic in the treatment of nosocomial pneumonia caused by Pseudomonas aeruginosa.
Thomas P. Lodise; Ben Lomaestro and George L. Drusano. Piperacillin-Tazobactam for Pseudomonas aeruginosa Infection: Clinical Implications of an Extended-Infusion Dosing Strategy. Clin Infect Dis.2007, 44, (3), 357-363.
K Bush; C Macalintal; B A Rasmussen; V J Lee and Y Yang. Kinetic interactions of tazobactam with beta-lactamases from all major structural classes. Antimicrob. Agents Chemother.1993, 37, (4), 851-858.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.