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Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.
Diamond, J.R.; Karnovsky, M.J. Focal and segmental glomerulosclerosis following a single intravenous dose of puromycin aminonucleoside. Am J Pathol. 1986, 122, (3), 481-487.
Dichiarazioni di rischio (UE): H302
Harmful if swallowed.
Dichiarazioni precauzionali: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.