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53-79-2 - Puromycin, 10 mg/ml in distilled water, sterile-filtered - J67236 - Alfa Aesar

J67236 Puromycin, 10 mg/ml in distilled water, sterile-filtered

Codice CAS
53-79-2
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1ml 48,50
5x1ml 176,00
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Puromycin, 10 mg/ml in distilled water, sterile-filtered

MDL
MFCD00012691

Proprietà chimiche

Modulo
Liquid
Solubilità
Soluble in water (50 mg/ml at 20°C).

Applicazioni

Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.

Note

Research Use only: Not intended for animal or human diagnostic or therapeutic use. Optimal working concentration of puromycin varies between cell lines. Usually, the working concentration for eukaryote cell culture is 1-10 µg/ml

Letteratura

Diamond, J.R.; Karnovsky, M.J. Focal and segmental glomerulosclerosis following a single intravenous dose of puromycin aminonucleoside. Am J Pathol. 1986, 122, (3), 481-487.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302

Harmful if swallowed.

Dichiarazioni precauzionali: P264-P270-P301+P312a-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
AU7350000

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