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67-66-3 - Chloroform, Molecular Biology Reagent - Trichloromethane - J67241 - Alfa Aesar

J67241 Chloroform, Molecular Biology Reagent

Codice CAS
67-66-3
Sinonimi
Trichloromethane

Dimensioni Prezzo ($) Quantità Disponibilità
500ml 53,80
1L 90,30
2.5L 184,00
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Chloroform, Molecular Biology Reagent

MDL
MFCD00000826
EINECS
200-663-8

Proprietà chimiche

Formula
CHCl3
Peso formula
119.38
Modulo
Liquid
Punto di fusione
-63°
Punto di ebollizione
61°
Densità
1.492
Indice di rifrazione
1.446
Solubilità
Soluble in water at 20°C 8 g/L.

Applicazioni

Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.

Note

Stabilized with approx. 50 ppm amylene

Letteratura

Auttachoat W, et al. Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water.Drug Chem. Toxicol.,2009,32(1), 77-87.

Lin YR, et al. Role of ryanodine receptors in chloroform-induced contraction in Swine tracheal smooth muscle.Toxicol Appl Pharmacol.,2002,183(2), 146-51.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H351-H361-H373-H302-H332-H315-H336

Suspected of causing cancer. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. May cause drowsiness or dizziness.

Dichiarazioni precauzionali: P260-P201-P261-P280-P281-P304+P340-P362-P301+P312-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,2141
Beilstein
1731042
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2903.13
TSCA
Yes
RTECS
FS9100000

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