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25316-40-9 - Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered - J67364 - Alfa Aesar

J67364 Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered

Codice CAS
25316-40-9
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1ml 252,00
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Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered

MDL
MFCD00077757
EINECS
246-818-3

Proprietà chimiche

Modulo
Liquid
Solubilità
Fully miscible in water and soluble in 50 mM in DMSO, methanol and isotonic sodium chloride (>10 mg/ml). Insoluble in chloroform, and ether.

Applicazioni

It acts as an antitumor antibiotic agent that inhibits DNA topoisomerase II and acts as a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. It reduces intracellular tau levels. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein. It is an is an inhibitor of AMPK, TERT and POLR. its fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. It is applied as an antineoplastic.

Note

Protect from heat. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in freezer at -20°C.

Letteratura

Patel, S, et. al. Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: Implications for the mechanisms of doxorubicin action and cytotoxicity.Mol Pharmacol.,1997,52(4), 658-666.

Lorenzo, E, et al. Doxorubicin induces apoptosis and CD95 gene expressionin human primary endothelial cells through a p53-dependent mechanism.J Biol Chem.,2002,277(17), 10883-10892.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H350

May cause cancer.

Dichiarazioni precauzionali: P201-P280-P202-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2941.90
TSCA
No
RTECS
QI9295900

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