Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

3039-71-2 - U-18666A, 95% - 3beta-[2-(Diethylamino)ethoxy]androstenone hydrochloride - J67389 - Alfa Aesar

J67389 U-18666A, 95%

Codice CAS
3039-71-2
Sinonimi
3beta-[2-(Diethylamino)ethoxy]androstenone hydrochloride

Dimensioni Prezzo ($) Quantità Disponibilità
5mg 68,80
10mg 120,00
25mg 287,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

U-18666A, 95%

MDL
MFCD00210908

Proprietà chimiche

Formula
C25H41NO2•HCl
Peso formula
424.06
Modulo
Solid
Solubilità
Soluble in water at 10mg/ml

Applicazioni

Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.

Note

Protect from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.

Letteratura

Koh, C.H.V, et al. Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C and Alzheimer’s disease.Cell Signal.,2006,18(11), 1844-1853.

Tabas, I. Apoptosis and plaque destabilization in atherosclerosis: The role of macrophage apoptosis induced by cholesterol.Cell Death Differ.,2004,11S12-S16.

Altri riferimenti

Codice tariffe armonizzato
2937.29
TSCA
No

Raccomandato

  • J60244

    MES lysis buffer with NP-40 (2X)
  • J67562

    Acetylated Angiotensin II, Certified Mass Spec Grade, 500pmol per vial
  • A10882

    Ethyl 3-amino-1H-pyrazole-4-carboxylate, 99%
  • L11128

    Heptafluoro-2,3,3-trichlorobutane, 98%
  • 43700

    Deuterium oxide, 99.95+% (Isotopic)

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio