Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

3019-71-4 - Trichloroacetyl isocyanate, 97% - L00226 - Alfa Aesar

L00226 Trichloroacetyl isocyanate, 97%

Codice CAS
3019-71-4
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
2g 31,60
10g 85,40
50g 379,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Trichloroacetyl isocyanate, 97%

MDL
MFCD00002033
EINECS
221-165-7

Proprietà chimiche

Formula
C3Cl3NO2
Peso formula
188.40
Punto di ebollizione
58-60°/20mm
Punto di infiammabilità
65°(149°F)
Densità
1.585
Indice di rifrazione
1.4800
Sensibilità
Moisture Sensitive
Solubilità
Miscible with dichloromethane, ether, terahydrofuran and protic solvents.

Applicazioni

Trichloroacetyl isocyanate is used as an in-situ derivatizing reagent for characterization of alcohols, glycols, phenols, and amines by nuclear magnetic resonance. It is also used in anion chemical ionization mass spectrometry and in catalytic one-pot dehydrative glycosylation of 1-hydroxy carbohydrate. Further, it serves as a reagent for the conversion of alcohols into carbamates.

Note

Moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with acids and strong oxidizing agents.

Letteratura

Reacts with nucleophiles to give ureas, carbamates, etc., from which the trichloroacetyl group can readily be removed. For reaction of acyl isocyanates with Grignard reagents to give primary carboxamides, see: Tetrahedron Lett., 981 (1975).

[2+2]-Cycloaddition with cyclic enol ethers gives fused azetidinones: Tetrahedron, 45, 227 (1989).

Causes characteristic chemical shifts in the ɑ-protons of alcohols by in situ conversion to the carbamates: Anal. Chem., 431 (1965).

Reviews: Chemistry of ɑ-haloisocyanates: Synthesis, 85 (1980). General isocyanate chemistry: Appendix 3.

Shajari, N.; Kazemizadeh, A. R.; Ramazani, A.; Joo, S. W.; Ślepokura, K.; Lis, T.; Souldozi, A. Facile synthesis and crystal structure of 1,5-dimethyl-6-thioxo-1,3,5-triazinane-2,4-dione. J. Struct. Chem. 2015, 56 (4), 806-810.

Szcześniak, P.; Stecko, S. An approach to asymmetric synthesis of beta-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement. RSC Adv. 2015, 5 (39), 30882-30888.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H330-H314-H318-H334

Combustible liquid. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Dichiarazioni precauzionali: P260u-P201-P280a-P304+P340-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
971201
Classe di rischio
6.1
Gruppo di imballaggio
II
Codice tariffe armonizzato
2929.10
TSCA
Yes

Raccomandato

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio